Enhanced metabolic bioavailability of tetrahydrocurcumin after oral supplementation of a γ-cyclodextrin curcumin complex
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چکیده
منابع مشابه
Pharmacokinetic Study of Nanoparticulate Curcumin: Oral Formulation for Enhanced Bioavailability
Curcumin, a bioactive component of turmeric, which is a commonly used spice and nutritional supplement, is isolated from the rhizomes of Curcuma longa Linn. (Zingiberaceae). In recent years, the potential pharmacological actions of Curcumin in inflammatory disorders, cardiovascular disease, cancer, Alzheimer’s disease and neurological disorders have been shown. However, the clinical application...
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Purpose: The solubility of coenzyme Q10 (CoQ10) in water is extremely low, resulting in a low oral bioavailability. In this study, we attempted to improve the low dissolution and bioavailability of CoQ10, by means of the complexation with natural α-, βand γ-cyclodextrins (CyDs) and 2-hydroxypropyl-β-CyD (HP-β-CyD). Methods: The complexation of CoQ10 with CyDs was studied by the solubility metho...
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Introduction: Cutaneous leishmaniasis (CL) is a widespread disease that is epidemic in Iran, too. Photodynamic therapy (PDT) is an attractive modality to treat cancer and hyper proliferative diseases based on the use of a photosensitizer in the presence of oxygen and proper wavelength of light. In consideration of lesion location, lack of systemic involvement and inefficiency of current treatme...
متن کاملΒ-cyclodextrin Inclusion Complex of Curcumin
Formation of inclusion complex of curcumin with β-cyclodextrin ( β-CD) has been characterized by absorption and fluorescence spectroscopy. From temperature-dependent fluorescence measurements, the thermodynamic parameters ∆H and ∆S, for the complexation were estimated. Kinetics of binding was studied by stopped flow technique, from which the binding constants for inclusion complex was estimated...
متن کاملBioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers
R-α-lipoic acid (R-LA) is a cofactor of mitochondrial enzymes and a very strong antioxidant. R-LA is available as a functional food ingredient but is unstable against heat or acid. Stabilized R-LA was prepared through complexation with γ-cyclodextrin (CD), yielding R-LA/CD. R-LA/CD was orally administered to six healthy volunteers and showed higher plasma levels with an area under the plasma co...
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ژورنال
عنوان ژورنال: Journal of Functional Foods
سال: 2021
ISSN: 1756-4646
DOI: 10.1016/j.jff.2021.104410